in compressive strength observed in binge alcohol-treated animals (p < 0.05) (Fig. 2C). The size of vertebral bodies as determined by cross-sectional area measurement obtained during pQCT was equivalent across treatment groups (data not shown), suggesting that the decreased BMD and vertebral compressive strength values observed after binge alcohol treatment were the result of altered mineral and biomechanical properties of the vertebrae and were not due to treatment-related differences in vertebral body area.