Although analyses in the AA sample also produced gene-wise significance for several genes, there was no overlap in the top genes in the two samples (Table 1). The most significant gene in the AA sample was KCNQ5 (potassium voltage-gated channel, KQT-like subfamily, member 5) with an empirical p=0.0002; this gene was also the only one to survive experiment-wide Bonferroni correction. Two genes achieved gene-wise significance with p-values of 0.001: SLC35B4 (solute carrier family 35, member B4) and MGLL (monoglyceride lipase). A further three genes showed gene-wise significance of p<0.05, specifically IL8 (interleukin 8), p=0.008, MORC1 (MORC family CW-type zinc finger 1), p=0.006 and CEACAM6 (carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen), p=0.023.
