Associations among immune-related comorbidities in OCD Collaborative Genetics Association Study probands with childhood-onset OCD. Significant associations described in Supplementary Table S4 are depicted by two-way arrows. Comorbidities include diseases with autoimmune (green; SLE, RA, MS), infectious (red; ear/throat infections, scarlet fever), combined autoimmune and infectious (RF), atopic (purple; asthma), and inflammatory (blue; psoriasis, IBD) etiologies, although recent data suggest significant overlap in pathophysiology and genetic predisposition among these conditions. All except for an association between IBD and rheumatic fever have been reported for the general population. IBD, inflammatory bowel disease; SLE, systemic lupus erythematosus; RA, rheumatoid arthritis; MS, multiple sclerosis; RF, rheumatic fever; OCD, obsessive compulsive disorder.
