It is important to note the reasons why the number of subjects reported here is relatively small. The analyses required that the subjects have both SRE and alcohol challenge values, these scores needed to be determined at about the same time to adequately compare their predictive values, and a follow-up was required. As a result, the original San Diego Prospective Study probands could not be used because the SRE had not been developed until more than a decade after the alcohol challenges. As for the broader COGA sample, while the SRE was added to the overall protocol about 8 years ago, only a small subgroup were given alcohol challenges.
