RII subunit of PKA are resistant to the intoxicating effects of ethanol (Park et al. 2000). In addition, PKA has been shown to alter GABAA receptor function. For example, PKA activation causes a decrease in GABA-activated currents in cultured cerebellar granule cells, hippocampal pyramidal cells, and spinal cord neurons (Moss et al. 1992; Poisbeau et al. 1999; Porter et al. 1990; Robello et al. 1993). Taken together, it is clear that PKA also plays a role in ethanol-mediated behavior and may influence GABAA receptor function.
