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Chunk #78 — 4. Advances — 4.2. Event-related brain potentials (ERPs) — 4.2.2. P3 component in oddball tasks

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Genetic psychophysiology: advances, problems, and future directions.
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Apart from the traditional peak amplitude, several follow-up publications from the same group focused on event-related oscillations (EROs) assessed in the same ERP experiment. In contrast to the ERP measures that are derived from event-locked EEG signal in the time domain averaged across multiple trials, EROs represent the same signal in the frequency domain, allowing for the estimation of brain oscillations in different frequency bands that are associated with the event of interest. These studies reported significant genetic associations between EROs in the delta and theta band elicited by the target stimulus and various genetic polymorphisms including the cholinergic muscarinic receptor gene (CHRM2) (Jones et al., 2004), serotonin receptor gene HTR7 (Zlojutro et al., 2011), glutamate receptor gene (GRM8) (Chen et al., 2009), corticotropin releasing hormone receptor 1 gene (CRHR1) (Chen et al., 2010) and association with KCNJ6, a gene related a potassium inward rectifier channel demonstrated in a GWAS study at genome-wide significance level (Kang et al., 2012). These studies suggest that EROs can capture separate aspects of the neural response elicited by the target stimulus that are distinct