Since the original publication of Enrichr in 2013 (14), we have systematically added new gene set libraries (Table 1). We created gene set libraries from HumanCyc (15), a metabolic pathway resource stored in BioPAX format (16); gene and small-molecule perturbations from the LINCS L1000 data set; NCI-Nature pathways (17); protein complexes from the NURSA project (18); pathways from the PANTHER resource (19); targets of phosphatases from DEPOD (20); human phenotypes from the Human Phenotype Ontology (HPO) (21); genes associated with grants using NIH RePORTER and GeneRIF (22); transcription factor targets computed from the ChIP-seq data from the ENCODE project (23); differentially expressed genes from the Allen Brain Atlas (24); tissue expression extracted from the Genotype-Tissue Expression (GTEx) project (25); protein expression in tissues and cell types from ProteomicsDB (26) and the Human Proteome Map (HPM) (27); genes associated with cell survival from the Achilles Project (28); and more. More details about constructing these new libraries are available as supporting online materials. These libraries are open source, freely available for download from the libraries page of Enrichr. In the updated version
