a recent study, they observed notable differences in the expression of genes associated with human AD among AD mice with various genetic backgrounds. Specifically, the B6.APP/PS1 and WSB.APP/PS1 strains displayed higher expression levels for the gene CLEC7A, while the CAST and PWK strains did not (75). These results suggest that genetic background may modulate microglial phagocytic function in response to ethanol and influence neuron function in AUD, potentially affecting the interaction between microglia and neuronal cells in the context of AUD pathophysiology.
