Self-reported lifetime prevalence of immune-related comorbidities included in the medical questionnaire is shown in Table 2. There were no cases of rheumatic heart disease. The prevalence of Sydenham's chorea and MS (one and two cases, respectively) was not significantly different from zero. Lifetime prevalence of SLE, type 1 diabetes (based on insulin dependence under age 40), asthma, psoriasis, and IBD was within the range expected based on population data (reviewed in Supplementary Table S2). Higher-than-expected prevalence was reported for encephalitis or meningitis (1.4 [0.9–2.1]% vs. 0.1%–0.4%, z = 5.913, p < 0.001, n = 1393), scarlet fever (4.0 [3.1–5.2]% vs. 1.0%–2.0%, z = 1.491, p < 0.001, n = 1389), RF (0.6 [0.3–1.2]% vs. 0.1%–0.2%, z = 3.338, p < 0.001, n = 1390), and RA (1.1 [0.6–2.0]% vs. 0.2%–0.4%, z = 3.416, p < 0.001, n = 949).
