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Chunk #20 — 3 Inverse solutions

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Review on solving the inverse problem in EEG source analysis.
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Various mathematical models are possible depending on the number of dipoles assumed in the model and whether one or more of dipole position(s), magnitude(s) and orientation(s) is/are kept fixed and which, if any, of these are assumed to be known. In the literature [10] one can find the following models: a single dipole with time-varying unknown position, orientation and magnitude; a fixed number of dipoles with fixed unknown positions and orientations but varying amplitudes; fixed known dipole positions and varying orientations and amplitudes; variable number of dipoles (i.e. a dipole at each grid point) but with a set of constraints. As regards dipole moment constraints, which may be necessary to limit the search space for meaningful dipole sources, Rodriguez-Rivera et al. [11] discuss four dipole models with different dipole moment constraints. These are (i) constant unknown dipole moment; (ii) fixed known dipole moment orientation and variable moment magnitude; (iii) fixed unknown dipole moment orientation, variable moment magnitude; (iv) variable dipole moment orientation and magnitude.