role in addiction, including AD. ALIGATOR analysis helped to highlight processes related to underlying mechanisms; the Australian/Dutch GWAS (Lind et al. 2010) also reported results with genes encoding transporters, cell adhesion molecules and cytoskeleton proteins. Structural homeostasis has been shown to play a role in the regulation of drug-induced neuroplasticity through regulation of scaffold protein and signal transduction (Szumlinski, Ary, and Lominac 2008).
