Thus, the effect of the mutation in the CACNA2D2 G>A allele will certainly affect the effectiveness of the opioid. It is also essential for the action of β-endorphin in pain processing pathways. The link between β-endorphin and the calcium channel may be reflected by the observation that this opioid affects the inhibitory action of OPMR1 on the calcium channel expressed on pathways involved in nociception [60].
