According to our primary analysis plan, no SNP-MDD phenotype association reached genomewide significance as the minimum q-value was 0.28, greater than the pre-defined q-value threshold of 0.10. This result was not unexpected. For example, type 2 diabetes mellitus has arguably reaped the greatest harvest from GWAS (82) and yet two of the initial T2DM GWAS were unremarkable when analyzed independently (83, 84). One of the key lessons of the GWAS era is the importance of meta-analysis where its application to the primary GWAS can uncover positive findings that replicate well across studies (18, 85).
