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Chunk #19 — Discussion

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Shared molecular genetic risk of alcohol dependence and posttraumatic stress disorder (PTSD).
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In conclusion, using summary statistics from the two largest GWAS of PTSD and AD, this study demonstrates a shared molecular genetic basis for the two disorders. Future studies should explore mechanisms underlying the comorbidity and shared genetic liability, the nature of the genetic correlation for these disorders, and expand into other genetically-informed approaches (e.g., functional studies, gene x gene interaction studies) in diverse samples of men and women.