Chunk #50 — Materials and Methods — Derivation of the sum-score

Source

Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics.

Embedded

yes

Text

It follows that zTz=zTΓΓTz=yTΛy∼∑iλiχ12, where λ i is the i-th eigenvalue of Σ and χ12 represents the chi-squared distribution.