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Chunk #21 — Results — AspPS predictivity in admixed genomes

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Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals.
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alone or European samples only, see Supplementary Fig. 7. Lastly, we compared models including casPS with the traditional total PS, performing a Vuong’s closeness test to detect which one fared better when predicting traits in admixed samples. For BMI, our approach resulted significantly closer to the real data than a traditional PS using either BBJ or UKBB associations, whereas for height the PS derived from UKBB still performed better (Supplementary Table 3).