We examined the cis associations between SNPs that reached genome-wide significance (P < 5 × 10-8) and expression of nearby genes in multiple tissues from 5 studies described previously: 1) subcutaneous adipose tissue (n=603) and whole blood (n=747) from deCode50; 2) lymphoblastoid cell lines (n=830) from a childhood asthma study51; 3) liver (n=707), subcutaneous fat (n=870) and omental fat (n=916) tissue from a bariatric surgery study52; 4) subcutaneous abdominal (N=52) and gluteal (N=62) adipose tissue and whole blood (n=65) from MolOBB53; and 5) cortical brain tissue (n=193) survey study.54 SNPs were tested for cis associations with transcripts within 500 kb or 1 Mb, assuming an additive effect of the BMI allele or using an ANOVA test with study-specific p-value thresholds used to account for multiple testing. Conditional analyses were performed for all expression data, except for cortical tissue, by conditioning the trait-associated SNP on the most significant cis-associated SNP for that particular gene transcript and vice versa.
