The Finland-United States Investigation of Non-Insulin-Dependent Diabetes Mellitus Genetics (FUSION) Study consists of 1,161 Finnish individuals with type 2 diabetes (T2D) and 1,174 normal glucose tolerant Finnish controls. Samples were genotyped with the Illumina Human-Hap300 BeadChip (v1.1). In sum, 306,222 autosomal SNPs passed quality control (HWE P ≥ 10−6 in the total sample, call frequency ≥ 0.90 and MAF > 0.01)15. In addition, 120 trios were genotyped with the same chip and haplotypes were estimated based on the most likely pattern of gene flow using Merlin20 and compared with haplotypes estimated statistically using population information and the software program MaCH12.
