rs1049353 was coded dichotomously as carriers of the minor allele (AA/AG) and those homozygous for the major allele (GG). Secondary analyses compared AA and AG genotypes separately. We selected this SNP because it is (a) widely studied in the context of mood, (b) is exonic and (c) was typed in both samples with high quality. No other SNPs in CNR1 or any other gene were examined.
