Chunk #61 — STAR* METHODS — QUANTIFICATION AND STATISTICAL ANALYSIS — Examination of the Impact of Sample Size Imbalance on Genetic Correlations and Genomic SEM Results
sizes when necessary. We then performed meta-analysis using ASSET (Bhattacharjee et al., 2012) and estimated m-values as was done in the original analysis. Finally, we compared the distribution of the number of pleiotropic loci across the 100 simulation replicates against the observed value in the actual study. For this analysis, we focused on chromosome 1 where the largest number of cross-disorder associations were identified in the actual analysis. Data S1.5 displays the distribution of the number of cross-disorder loci identified in meta-analysis of chromosome 1 across 100 simulation replicates. We compared this to the number of pleiotropic loci found in our meta-analysis compared to those seen in the simulations, given the sample size and genetic correlations among the eight disorders to determine whether the observed number of pleiotropic loci exceeds chance expectation.
