Second, we obtained ratings from 24 schizophrenia geneticists. The mean ratings were ≥4 for only DRD2 and GRM3. The mean ratings were inconsistent with those from informed investigators for AKT1, CHRNA7, DISC1, and HTR2A. Note that all ratings could incorporate any type of genetic variation. In general, we found that empirical data and opinion agreed for most of the 25 candidate genes, and the discrepancies for AKT1, CHRNA7, DISC1, and HTR2A stand out. Several informed investigators address this issue and believe that genetic results that do not meet widely accepted standards for significance in genetics or which lack replication can be augmented by biological data (Supplement). To this view, biological plausibility can provide salience to chance-level genetic results.
