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Chunk #12 — Material and methods — Measures of spectral power and phase–amplitude coupling

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Subthalamic nucleus phase-amplitude coupling correlates with motor impairment in Parkinson's disease.
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channel: (1) with time series concatenated across all epochs to assess the overall PAC; (2) for each epoch individually. The latter results in a set of β-coefficients, which we used to test for significance of the overall PAC via an F-test. The actual PAC values reported in the paper were estimated after concatenation of time series across epochs. More details of this method can be found in van Wijk et al. (2015). The corresponding Matlab code is implemented within the open-source SPM toolbox (http://www.fil.ion.ucl.ac.uk/spm/, Litvak et al., 2011b).