gene expression dataset on the Reactome event hierarchy often yields results that are not readily viewed by a human user. To solve this display problem, we have developed an alternative display option based on Voronoi diagrams (Wikipedia. Voronoi diagram https://en.wikipedia.org/w/index.php?title=Voronoi_diagram&oldid=908392936 (accessed 26 August 2019)). The resulting pathway display (Figure 5B) is partitioned into contiguous regions, each corresponding to a pathway and grouped according to the relationships among pathways specified in the event hierarchy. This arrangement devotes maximum possible space in the diagram to the pathway nodes. Figure 5 shows our metabolism node, comparing its fireworks and Voronoi diagram layouts.
