paperKB
coga / coga-kb
Help
Sign in

Chunk #20 — Materials and Methods — Statistical analysis — Selection of PC for PS correction

Source
Population substructure and control selection in genome-wide association studies.
Embedded
yes

Text

Our selection procedure attempts to include only PCs that are useful for the correction of PS. A PC is chosen whenever its inclusion can significantly reduce the inflation in type I error rate, measured by the over-dispersion factor, in comparison with the addition of a randomly generated covariate. Once a set of PCs has been identified, they are adjusted with other covariates in a standard logistic regression model.