Chunk #22 — Molecular basis for the effect of maternal care on HPA responses to stress

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Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome.

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Maternal LG results in an increased expression of NGFIA, which in turn might then regulate GR expression. Other rodent models examining environmental regulation of hippocampal GR expression also suggest a correspondence between NGFIA levels and GR expression.81,82 In each case, increased levels of NGFIA are associated with enhanced GR expression. However, the critical site for GR regulation remains to be defined.