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Chunk #21 — Methods — Factor analysis of clinical dimensions of SCZ across multiple datasets

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Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.
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In order to test the comparability of symptom factors across PANSS and OPCRIT, we performed EFA in the Dublin sample, which used both instruments. Pearson product-moment correlations were calculated for each of the resulting factors across these two instruments. These were the only two instruments that were used in the same sample. All factors except Positive were significantly correlated (r=.48 for depressive, .70 for manic, and .85 for negative symptoms, indicating that the two instruments index the same broad underlying constructs for these dimensions.