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Chunk #30 — DISCUSSION

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Microstructural abnormalities in callosal fibers and their relationship with cognitive function in schizophrenia: A tract-specific analysis study.
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The SZ group demonstrated decreased FA values in the temporal segments of CC white matter fibers relative to the HC group. Impairment in the temporal lobe with schizophrenia was reported repeatedly. Ellison‐Wright and Bullmore carried out meta‐analysis of the coordinates of fractional anisotropy differences (Ellison‐Wright & Bullmore, 2009). This meta‐analysis of 15 studies (including a total of 407 patients with schizophrenia and 383 comparison subjects) found that significant reductions were present in the left frontal deep white matter and the left temporal deep white matter (Ellison‐Wright & Bullmore, 2009). The second region, in the temporal lobe, is traversed by WM tracts interconnecting the frontal lobe, insula, hippocampus–amygdala, and temporal and occipital lobe. This suggests that WM tracts in the temporal lobe may affect in schizophrenia, with the disconnectivity of the gray matter regions which they link. Decreased FA values of the CC on the DTI whole‐brain analysis in schizophrenia have been repeatedly reported in the rostrum (Ellison‐Wright et al., 2014; Fujino et al., 2014; Gu et al., 2016; Hummer et al., 2016; Kochunov et al., 2014; Kong et al., 2011;