Chunk #68 — Discussion — Role of FGFR1

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Cerebral organoids reveal early cortical maldevelopment in schizophrenia-computational anatomy and genomics, role of FGFR1.

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The early cortical malformations revealed by this organoid study could underlie the disruption of cortical layers, cell paucity, hypoplasia, abnormal connections, and white matter tracks observed in adult schizophrenia brains by pathological examination and/or in vivo imaging17,60.