significant target of interest in prenatal stress research. Bdnf exon I hypomethylation was reported 24 h following PD4–9 alcohol exposure in the male rat hippocampus; this reduction in methylation was correlated with increased exon I-driven Bdnf gene expression (Boschen et al., 2015). However, by PD72, methylation status had returned to control levels (Boschen et al., 2016). Bdnf and other growth factors that could contribute to either delayed embryonic growth or long-term deficits in neuroplasticity need to be further investigated from an epigenetic perspective.
