paperKB
coga / coga-kb
Help
Sign in

Chunk #11 — Materials and Methods — SNP associations with DNAm and RNAexp

Source
Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence.
Embedded
yes

Text

We assessed SNP associations with RNAexp of nearby genes (+/− 1Mb around the transcription start sites) across adult brain tissues from the Genotype-Tissue Expression (GTEx) project37 with 1000G-imputed genotypes and RNA sequencing measures from up to 103 deceased persons. We followed up cis-eQTL SNP results in the Brain eQTL Almanac dataset (N=134 EUR deceased persons, http://www.braineac.org/), using RNAexp probes measured on Affymetrix Human Exon 1.0 ST arrays across brain tissues, many of which overlap with tissues available in GTEx.38