To understand potential disease-related functions of NEAT1, we examined existing literature, and found that the chromosomal locus containing NEAT1, 11q13, is in fact a region implicated in idiopathic generalized seizures24. Furthermore, NEAT1 was previously found to be up-regulated in a small cohort of patients with intractable seizures25. We then extended these initial observations with an additional 14 seizure patient samples, and found that these also display significantly up-regulated NEAT1 expression in high versus low activity regions resected from the brains of affected individuals (Fig. 4a,b).
