As multiple recent studies suggested overlapping risks among divergent neuropsychiatric disorders, including ASD, SCZ, and ID (40, 44, 55), we next adopted previously defined gene lists from recent large scale studies of these disorders to evaluate genic overlap with TS (38, 55, 56). We found a significant enrichment of genes classified as “ASD implicated” (2% vs. 0.4%, p=0.006) and “ASD implicated + ASD candidates” (10.2% vs. 5.7%, p=0.002) among individuals with TS versus matched controls (Table 2, Figure 2). This enrichment withstands correction for multiple comparisons. In contrast, no significant overlap was observed with either ID (p=0.9) or SCZ (p=0.2) gene lists (Figure 2).
