To compare the sensitivity of feeding versus injection in detecting phenotypes from randomly selected genes, we tested 86 genes from the middle of C. elegans chromosome I on consecutive cosmids from K04G2 to R05D11. Of these genes, 12 yielded a phenotype by injection and 13 by feeding (Table 4). These data suggest that feeding and injection are similarly sensitive for detecting genes that give an RNAi phenotype. The number of phenotypes detected in this experiment is, however, too small to allow a fair comparison of the strengths of the two methods.
