The dynorphin/KOR system has emerged as a potential target for the treatment of alcohol and drug dependence. We showed here that KOR ligands decrease inhibitory transmission in CeA neurons and interfere with the physiological effects of ethanol. We also uncovered a dynorphin/KOR tone that influences neuronal activity in the CeA, a brain structure that plays a major role in alcohol dependence and reinforcement. Further studies will determine the influence of chronic alcohol treatment on the cellular effects elicited by the dynorphin/KOR system and its interactions with other neuromodulators (e.g., Corticotropin-Releasing Factor) implicated in CeA signaling in the alcohol-dependent organism.
