or uncommon alterations in very common tumors (for example, Erlotinib and EGFR-L858R in non-small cell lung cancer) [2]. The identification of an increasing number of somatic tumor mutations common across cancers arising from different tissues has begun to encourage molecularly defined clinical trials in which subjects with cancers from a number of differing sites of origin are eligible. To accelerate this paradigm shift, an assay capable of broad mutation testing in heterogeneous tumor samples is needed.
