We tested whether SNPs in the 7 chromosome regions associated with SC were also associated with DSM-IV AD. Our association analysis using a GEE model found none of the genotyped SNPs in these regions attained genome-wide significance with DSM-IV AD. By comparing the associations for SC with DSM-IV AD, we observed a less significant association with the dichotomous diagnostic trait than the association with SC (Table 1). However, the effect sizes between the two phenotypes were highly correlated (Figure 4).
