To provide a more complete description of the gene model, a “status” is assigned at both the locus and transcript level. Loci can be assigned the status “known,” “novel,” or “putative” depending on their presence in other major databases and the evidence used to build their component transcripts. In brief, loci have the status “known” if they are represented in the HUGO Gene Nomenclature Committee (HGNC) database (Seal et al. 2011) and RefSeq (Pruitt et al. 2012); loci with the status “novel” are not currently represented in those databases but are well supported by either locus-specific transcript evidence or evidence from a paralogous or orthologous locus. Finally loci with status “putative” are supported by shorter, more sparse transcript evidence. A similar status categorization is employed at the transcript level (see Supplemental Figures and Tables).
