Chunk #72 — Dissection of the molecular mechanisms linking maternal behavior and active demethylation of GR exon 17 promoter in the hippocampus

Source

Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome.

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promoter through an increase in cAMP Since increased cAMP activates NGFIA, it seems that ectopic expression of NGFIA can target the demethylation process to the GR exon 17 promoter. Indeed, there is direct evidence that NGFIA can actively target methylated DNA binding proteins to specific sites around the NGFIA response element. While this finding provides evidence for a targeting process, it does not explain the selective effect at the 5' cytosine.