Aging is associated with a gradual decrease in brain volume, a process that accelerates notably in the later stages of life. 1 This decline is evident both globally and regionally across various brain regions. The hippocampus, a pivotal center for cognitive functions such as spatial and episodic memory, is among the most extensively studied regions due to its vulnerability to age‐related atrophy and involvement in Alzheimer's disease (AD) pathogenesis. 2 As one of the earliest and most severely affected regions in AD, the hippocampus exhibits significant neurodegeneration before clinical symptom onset. 3
