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Chunk #13 — Results — 14% of cortex cis-eQTLs are dependent on the cell-type proportion

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Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases.
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We used Decon-QTL19 to identify ieQTLs for the 25,497 independent Cortex-EUR cis-eQTLs: 3,549 cis-eQTLs (13.9%) showed at least one significant ieQTL (4,095 ieQTLs; Benjamini–Hochberg false discovery rate (BH-FDR) < 0.05; Supplementary Table 8). The largest group of interactions were with excitatory, inhibitory and other neurons (1,627; 39.7%), probably because neurons are the most prevalent cell type. The majority of the ieQTLs (3,090; 75.5%) were uniquely mapped to one cell type (Fig. 4c), although we cannot exclude the possibility that these ieQTLs are also present in other cell types.