The aims of the InterAct Project extend beyond the establishment of the InterAct case-cohort study and investigation of gene-lifestyle interaction using prospective observational studies. To enable InterAct partners to take gene-lifestyle interactions identified in the observational part of the study forward to a trial setting, a consortium of lifestyle intervention diabetes prevention trials ready for genotyping has been established. To better understand the impact of genetic risk information for preventive action, a Cochrane systematic review of the provision of risk information on emotion, cognition and behaviour has been completed, suggesting that the communication of DNA-based disease risk estimates may have little or no effect on behaviour, but may have a small effect on intentions to change behaviour [32].
