Chunk #47 — Reasons to be Concerned about the Published cGxE Literature — Problems with the Recipe: Statistical Concerns in cGxE Research — Power to detect and characterize different types of interactions
Yet another concern is the low power to detect most plausible forms of interactions in the first place (McClelland & Judd, 1993) in observational field studies as compared to experimental studies where independent variables can be efficiently manipulated. Under many conditions, theoretically meaningful interactions are likely to be quite small, accounting for 1% of the outcome variance and the power to detect most plausible interactions will be quite limited without large N.
