In conclusion, we have shown that none of the SNPs tagging the genes previously reported to determine lung function were significantly associated with FEV1 or FEV1/FVC ratio in the SpiroMeta general population study. We found some evidence to suggest a possible contribution for the SERPINA1 and PDE4D loci to lung function in smokers which warrant further study. As a resource to the scientific community we have provided the complete association results (Dataset S1) in the online supporting information.
