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Chunk #40 — 4. Discussion — 4.2. Poor Neuropsychological Performance in AUD

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Random Forest Classification of Alcohol Use Disorder Using fMRI Functional Connectivity, Neuropsychological Functioning, and Impulsivity Measures.
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also interfere with higher cognitive processes during task performance or real-life functioning that involve these visual memory processes. In our previous study on the same groups of subjects, we reported that the AUD group had a smaller bilateral hippocampal volume [6] and that lower volumes in prefrontal cortex and left hippocampus were associated with poorer visuospatial memory performance [6]. Furthermore, the hyperconnectivity across parahippocampal hub in the current study may also be related to the visual memory deficit, possibly representing a compensatory mechanism during the memory performance. On the other hand, in the context of numerous reports of impaired executive functioning in AUD [8], it was surprising to find that the TOLT variables failed to emerge as important features for classification. It is possible that the AUD sample in our study, due to their abstinent status, manifested significant deficits mainly in visual short-term memory in the VST but the executive functioning as tapped by the TOLT was either largely recovered due to abstinence. Furthermore, it is also possible that TOLT scores might be more relevant in the RF model involving FC features of other networks during resting state (e.g., executive control, attentional, etc.) or task performance (e.g., response inhibition, reward