Chunk #22 — Discussion

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Amyloid precursor protein (APP) regulates synaptic structure and function.

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be reliably assessed in the x-y plane and omits the spines in the z-plane, thus resulting in a significant underestimation of spine density (Duan et al., 2003). Nevertheless, the results of our study support the hypothesis that APP is crucial for maintaining dendritic morphology and spine structures as well as synaptic plasticity.