alterations within microglia, oligodendrocytes, and astrocytes in female individuals with OUD were significantly enriched for FKBP5 target genes identified in rodents administered opioids. Genes related to synaptic functions were also enriched in astrocytes of females, while enrichment was mostly in MSNs and interneurons in male individuals with OUD, suggesting sex-specific alterations of striatal neuronal and glial cell signaling in opioid addiction.
