20 bins, restricted to odd (resp. even) chromosomes excluding the target chromosome; and (5) setting prior causal probabilities for SNPs on the target chromosome proportional to per-SNP heritabilities from step 4. The L2 regularization in step 1 improves the accuracy of per-SNP heritability estimation; the partitioning into odd and even chromosomes in steps 1–2 and the exclusion of the target chromosome in step 4 prevents winner’s curse; and the re-estimation of per-SNP heritabilities in step 4 ensures robustness to model misspecification.
