Meta-analyses performed on these SNPs using data from the three samples found GWS association for five of the six CNIH3 SNPs (Table 2). The strongest meta-analytic association signal (p=4.30 E-9) was observed for rs10799590; the odds ratio [0.64 (95%CI 0.55 – 0.74)] is indicative of the risk allele’s robust protective effects. Rs1436175, which had the lowest p value in the CATS, failed to reach meta-analytic GWS. This SNP has the lowest LD with the other CNIH3 SNPs (r2=0.35–0.54) and the largest heterogeneity chi-square (p=0.002). The meta-analytic GWS SNPs are in high LD (Figure S2, Panels C and D).
