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Chunk #50 — Online methods — Replication analysis of previously-described SNPs in GERA

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Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.
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To determine how many of the 85 previously-described loci from ICBP and other GWAS replicated in this study, we tested the sentinel SNPs from those studies in our dataset4–22. Frequently, multiple BP phenotypes are reported for the same loci. We used a Bonferroni correction for replication (85 SNPs, α=0.00059). The SNP rs2446849 was not in our reference panel, so we used the closest proxy, rs2513758, at a physical distance of 876bp and r2=1.00 in Europeans.