In conclusion, we identified use disorder specific effects on neural oscillatory activity during a visual-spatial processing task. Amongst a sample of cannabis and alcohol users, reductions in the occipital alpha response were seen in individuals with AUD, and this scaled with increasing severity of AUD. Given that our model included main effects of both AUD and CUD, our AUD findings were statistically independent of CUD, which could reflect the specificity of alpha reductions in AUD. Overall, our findings suggest alpha oscillatory activity may play an integral role in the neural networks related principally to alcohol addiction. With further study, this neural activity could be used not only to further understand the circuitry of AUD, but may even be useful as a phenotypic marker of AUD.
